Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs

Burke, Philip, Chun Wong, Lai, Jenkins, Terence, Knox, Richard, Meikle, Ian and Stanforth, Stephen (2016) Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs. Bioorganic & Medicinal Chemistry Letters, 26 (24). pp. 5851-5854. ISSN 0960-894X

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BMCL article for NRL Nov 2016.docx - Accepted Version
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BMCL article for NRL Nov 2016.pdf - Accepted Version
Restricted to Repository staff only until 11 November 2017.

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Official URL: http://dx.doi.org/10.1016/j.bmcl.2016.11.024

Abstract

A series of N-nitroarylated-3-chloromethyl-1,2,3,4-tetrahydroisoquinoline derivatives, several of which also possessed a trifluoromethyl substituent, were prepared and assessed as potential nitroaromatic prodrugs. The enzymatic reduction of these compounds and their cytotoxicities were studied. The compounds were cytotoxic, but this is probably not related to their enzymatic reduction.

Item Type: Article
Uncontrolled Keywords: nitrogen mustards, NQO1, nitroreductase, CB 1954, nitroaromatic prodrugs
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Ay Okpokam
Date Deposited: 14 Nov 2016 09:55
Last Modified: 11 May 2017 04:51
URI: http://nrl.northumbria.ac.uk/id/eprint/28508

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