Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive pulmonary disease.

Louvaris, Zafeiris, Habazettl, Helmut, Asimakos, Andreas, Wagner, Harrieth, Zakynthinos, Spyros, Wagner, Peter and Vogiatzis, Ioannis (2017) Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive pulmonary disease. Respiratory Physiology and Neurobiology, 237. pp. 42-50. ISSN 1569-9048

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Louvaris et al - Heterogeneity of blood flow and metabolism during exercise in COPD (RESPNB 2017).pdf - Accepted Version
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Official URL: http://dx.doi.org/10.1016/j.resp.2016.12.013

Abstract

The study investigated whether the capacity to regulate muscle blood flow (Q) relative to metabolic demand (VO2) is impaired in COPD. Using six NIRS optodes over the upper, middle and lower vastus lateralis in 6 patients, (FEV1:46 ± 12%predicted) we recorded from each: a) Q by indocyanine green dye injection, b) VO2/Q ratios based on fractional tissue O2 saturation and c) VO2 as their product, during constant-load exercise (at 20%, 50% and 80% of peak capacity) in normoxia and hyperoxia (FIO2:1.0). At 50 and 80%, relative dispersion (RD) for Q, but not for VO2, was greater in normoxia (0.67 ± 0.07 and 0.79 ± 0.08, respectively) compared to hyperoxia (0.57 ± 0.12 and 0.72 ± 0.07, respectively). In both conditions, RD for VO2 and Q significantly increased throughout exercise; however, RD of VO2/Q ratio was minimal (normoxia: 0.12–0.08 vs hyperoxia: 0.13–0.09). Muscle Q and VO2 appear closely matched in COPD patients, indicating a minimal impact of heterogeneity on muscle oxygen availability at submaximal levels of exercise.

Item Type: Article
Uncontrolled Keywords: Chronic obstructive pulmonary disease; Muscle perfusion; Muscle metabolism; Exercise; NIRS
Subjects: A100 Pre-clinical Medicine
Department: Faculties > Health and Life Sciences > School of Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Ioannis Vogiatzis
Date Deposited: 10 Jan 2017 11:54
Last Modified: 12 Sep 2017 14:13
URI: http://nrl.northumbria.ac.uk/id/eprint/29099

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