Synthesis and biological evaluation of novel amidinourea and triazine congeners as inhibitors of MDA-MB-231 human breast cancer cell proliferation

Castagnolo, Daniele, Bass, Rosemary, Jenkinson, Sarah, Wright, Jennifer, Smulders-Srinivasan, Tora and Marshall, Jamie (2017) Synthesis and biological evaluation of novel amidinourea and triazine congeners as inhibitors of MDA-MB-231 human breast cancer cell proliferation. ChemMedChem, 12 (4). pp. 288-291. ISSN 1860-7179

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Official URL: http://dx.doi.org/10.1002/cmdc.201600580

Abstract

A series of novel amidinourea derivatives has been synthesised and the new compounds have been evaluated as inhibitors of MDA-MB-231 human breast cancer cell proliferation. In addition, a second series of triazine derivatives designed as rigid congeners of the amidinoureas was synthesised as well and the compounds were evaluated for their antiproliferative activity. Among the two series, the amidinourea 3d emerged as a potent anticancer hit compound with IC50 = 0.76 micormolar comparable to tamoxifen.

Item Type: Article
Uncontrolled Keywords: amidinourea, triazine, breast cancer, MDA-MB-231 cells, cell proliferation
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 19 Jan 2017 13:10
Last Modified: 09 May 2017 07:54
URI: http://nrl.northumbria.ac.uk/id/eprint/29228

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