Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies

Mantso, Theodora, Goussetis, George, Franco, Rodrigo, Botaitis, Sotiris, Pappa, Aglaia and Panagiotidis, Mihalis (2016) Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies. Seminars in Cancer Biology, 37-38. pp. 96-105. ISSN 1044-579X

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Official URL: http://dx.doi.org/10.1016/j.semcancer.2016.03.004

Abstract

Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (over the last few decades) since various studies have shed light into understanding hyperthermia's underlying molecular mechanism(s) of action. In general, hyperthermia is applied as complementary (adjuvant) means in therapeutic protocols combining chemotherapy and/or irradiation both of which can induce irreversible cellular DNA damage. Furthermore, according to a number of in vitro, in vivo and clinical studies, hyperthermia has been shown to enhance the beneficial effects of DNA targeting therapeutic strategies by interfering with DNA repair response cascades. Therefore, the continuously growing evidence supporting hyperthermia's beneficial role in cancer treatment can also encourage its application as a DNA repair mitigation strategy. In this review article, we aim to provide detailed information on how hyperthermia acts on DNA damage and repair pathways and thus potentially contributing to various adjuvant therapeutic protocols relevant to more efficient cancer treatment strategies.

Item Type: Article
Uncontrolled Keywords: Hyperthermia; DNA damage; DNA repair; Cancer therapeutics; Cancer treatment
Subjects: B900 Others in Subjects allied to Medicine
C400 Genetics
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 20 Jan 2017 08:33
Last Modified: 25 Oct 2017 17:16
URI: http://nrl.northumbria.ac.uk/id/eprint/29242

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