Effect of acute hypoxia on cognition: A systematic review and meta-regression analysis

McMorris, Terry, Hale, Beverley, Barwood, Martin, Costello, Joseph and Corbett, Jo (2017) Effect of acute hypoxia on cognition: A systematic review and meta-regression analysis. Neuroscience & Biobehavioral Reviews, 74. pp. 225-232. ISSN 0149-7634

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Official URL: http://dx.doi.org/10.1016/j.neubiorev.2017.01.019

Abstract

A systematic meta-regression analysis of the effects of acute hypoxia on the performance of central executive and non-executive tasks, and the effects of the moderating variables, arterial partial pressure of oxygen (PaO2) and hypobaric versus normobaric hypoxia, was undertaken. Studies were included if they were performed on healthy humans; within-subject design was used; data were reported giving the PaO2 or that allowed the PaO2 to be estimated (e.g. arterial oxygen saturation and/or altitude); and the duration of being in a hypoxic state prior to cognitive testing was ≤6 days. Twenty-two experiments met the criteria for inclusion and demonstrated a moderate, negative mean effect size (g = −0.49, 95% CI −0.64 to −0.34, p < 0.001). There were no significant differences between central executive and non-executive, perception/attention and short-term memory, tasks. Low (35–60 mmHg) PaO2 was the key predictor of cognitive performance (R2 = 0.45, p < 0.001) and this was independent of whether the exposure was in hypobaric hypoxic or normobaric hypoxic conditions.

Item Type: Article
Uncontrolled Keywords: arterial partial pressure of oxygen, normobaric, hypobaric, central executive, perception, short-term memory
Subjects: C800 Psychology
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Ay Okpokam
Date Deposited: 14 Feb 2017 15:02
Last Modified: 27 Oct 2017 10:57
URI: http://nrl.northumbria.ac.uk/id/eprint/29727

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