Innate Immunity in Systemic Sclerosis

Dowson, Christopher, Simpson, Nathan, Duffy, Laura and O'Reilly, Steven (2017) Innate Immunity in Systemic Sclerosis. Current Rheumatology Reports, 19 (1). ISSN 1523-3774

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Official URL: http://dx.doi.org/10.1007/s11926-017-0630-3

Abstract

Purpose of Review

Systemic sclerosis (SSc) is a heterogeneous autoimmune disease which has defined three hallmarks: Small vessel vasculopathy, production of autoantibodies and fibroblast dysfunction. The exact aetiology of the disease remains unknown, due to the complex nature of the cellular signalling pathways involved. However, there is strong and consistent evidence that the innate system, in particular toll-like receptor signalling, is contributing to the progression and perhaps onset of systemic sclerosis. In light of this evidence, this review examines the role of innate immunity in systemic sclerosis and where appropriate suggests avenues for therapeutic modulation in SSc.

Recent Findings

Multiple lines of evidence suggest that Toll-like receptors (TLRs) are dysregulated and emerging evidence suggests that many endogenous ligands are also elevated in the disease leading to ‘sterile inflammation’ and ultimately the induction of fibrosis. Currently, no effective therapy exists and exploiting the innate immune system perturbation may be one possible avenue.

Item Type: Article
Uncontrolled Keywords: systemic sclerosis, SSc, scleroderma, autoimmune disease
Subjects: B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Ay Okpokam
Date Deposited: 14 Feb 2017 14:50
Last Modified: 24 Oct 2017 11:23
URI: http://nrl.northumbria.ac.uk/id/eprint/29731

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