Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials

Wesnes, Keith, Brooker, Helen, Ballard, Clive, McCambridge, Laura, Stenton, Robert and Corbett, Anne (2017) Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. International Journal of Geriatric Psychiatry, 32 (12). e83-e92. ISSN 0885-6230

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Official URL: http://dx.doi.org/10.1002/gps.4659


Objective - The advent of long-term remotely conducted clinical trials requires assessments which can be administered online. This paper considers the utility, reliability, sensitivity and validity of an internet-based system for measuring changes in cognitive function which is being used in one such trial.

Methods - The Platform for Research Online to investigate Genetics and Cognition in Ageing is a 10-year longitudinal and entirely remote study launched in November 2015. The CogTrackTM System is being used to monitor changes in important aspects of cognitive function using tests of attention, information processing and episodic memory. On study entry, the participants performed CogTrackTM up to three times over seven days, and these data are evaluated in this paper.

Results - During the first six months of the study, 14 531 individuals aged 50 to 94 years enrolled and performed the CogTrackTM System, 8627 of whom completed three test sessions. On the first administration, 99.4% of the study tasks were successfully completed. Repeated testing showed training/familiarisation effects on four of the ten measures which had largely stabilised by the third test session. The factor structure of the various measures was found to be robust. Evaluation of the influence of age identified clinically relevant declines over the age range of the population on one or more measures from all tasks.

Conclusions - The results of these analyses identify CogTrackTM to be a practical and valid method to reliably, sensitively, remotely and repeatedly collect cognitive data from large samples of individuals aged 50 and over.

Item Type: Article
Uncontrolled Keywords: the PROTECT study; remote cognitive testing; attention; memory
Subjects: C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Becky Skoyles
Date Deposited: 21 Feb 2017 15:01
Last Modified: 26 Mar 2018 09:06
URI: http://nrl.northumbria.ac.uk/id/eprint/29820

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