New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections

Dover, Lynn, Bhatt, Apoorva, Bhowruth, Veemal, Willcox, Benjamin and Besra, Gurdyal (2008) New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections. Expert Review of Vaccines, 7 (4). pp. 481-497. ISSN 1476-0584

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Official URL: http://dx.doi.org/10.1586/14760584.7.4.481

Abstract

Tuberculosis remains the most common cause of death due to a single infective organism. Despite the availability of a vaccine and chemotherapeutic options, the global disease burden remains relatively unaffected. The ability of the mycobacterial etiological agents to adopt a semidormant, phenotypically drug-resistant state requires that chemotherapy is both complex and lengthy. The emergence of drug resistance has raised the possibility of virtually untreatable tuberculosis. Furthermore, the currently used bacillus Calmette–Guerin vaccine has had mixed success in protecting susceptible populations. Given this backdrop, the need for novel anti-infectives and more effective vaccines is clearly evident. Recent progress, described herein, has seen the development and entry into clinical trials of several new drugs and vaccine candidates

Item Type: Article
Subjects: A100 Pre-clinical Medicine
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 11 May 2010 10:41
Last Modified: 19 May 2017 09:18
URI: http://nrl.northumbria.ac.uk/id/eprint/3030

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