Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism

Anandhan, Annadurai, Jacome, Maria, Lei, Shulei, Hernandez-Franco, Pablo, Pappa, Aglaia, Panagiotidis, Mihalis, Powers, Robert and Franco, Rodrigo (2017) Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism. Brain Research Bulletin, 133. pp. 12-30. ISSN 0361-9230

[img] Text (Article)
Brain research Bulletin.pdf - Accepted Version
Restricted to Repository staff only until 21 March 2018.

Download (3MB) | Request a copy
Official URL: https://doi.org/10.1016/j.brainresbull.2017.03.009

Abstract

The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson’s disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechanisms linking these PD risk factors to neuronal dysfunction are still unclear. Alterations in redox homeostasis and bioenergetics (energy failure) are thought to be central components of neurodegeneration that contribute to the impairment of important homeostatic processes in dopaminergic cells such as protein quality control mechanisms, neurotransmitter release/metabolism, axonal transport of vesicles and cell survival. Importantly, both bioenergetics and redox homeostasis are coupled to neuro-glial central carbon metabolism. We and others have recently established a link between the alterations in central carbon metabolism induced by PD risk factors, redox homeostasis and bioenergetics and their contribution to the survival/death of dopaminergic cells. In this review, we focus on the link between metabolic dysfunction, energy failure and redox imbalance in PD, making an emphasis in the contribution of central carbon (glucose) metabolism. The evidence summarized here strongly supports the consideration of PD as a disorder of cell metabolism.

Item Type: Article
Additional Information: PMID:28341600
Uncontrolled Keywords: Neurodegeneration, Glycolysis, Glucose, TCA cycle, Oxidative stress, Bioenergetics, Mitochondria
Subjects: A300 Clinical Medicine
C900 Others in Biological Sciences
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Ay Okpokam
Date Deposited: 15 May 2017 08:36
Last Modified: 26 Sep 2017 07:35
URI: http://nrl.northumbria.ac.uk/id/eprint/30740

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics


Policies: NRL Policies | NRL University Deposit Policy | NRL Deposit Licence