Development of ciprofloxacin-loaded contact lenses using fluorous chemistry

Qin, Guoting, Zhu, Zhiling, Li, Siheng, McDermott, Alison and Cai, Chengzhi (2017) Development of ciprofloxacin-loaded contact lenses using fluorous chemistry. Biomaterials, 124. pp. 55-64. ISSN 0142-9612

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Official URL: https://doi.org/10.1016/j.biomaterials.2017.01.046

Abstract

In this work, we developed a simple method to load drugs into commercially available contact lenses utilizing fluorous chemistry. We demonstrated this method using model compounds including fluorous-tagged fluorescein and antibiotic ciprofloxacin. We showed that fluorous interactions facilitated the loading of model molecules into fluorocarbon-containing contact lenses, and that the release profiles exhibited sustained release. Contact lenses loaded with fluorous-tagged ciprofloxacin exhibited antimicrobial activity against Pseudomonas aeruginosa in vitro, while no cytotoxicity towards human corneal epithelial cells was observed. To mimic the tear turnover, we designed a porcine eye infection model under flow conditions. Significantly, the modified lenses also exhibited antimicrobial efficacy against Pseudomonas aeruginosa in the ex vivo infection model. Overall, utilizing fluorous chemistry, we can construct a drug delivery system that exhibits high drug loading capacity, sustained drug release, and robust biological activity.

Item Type: Article
Uncontrolled Keywords: Fluorous chemistry; Contact lenses; Drug delivery; Antimicrobial activity
Subjects: B500 Ophthalmics
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 19 May 2017 14:33
Last Modified: 06 Sep 2017 12:41
URI: http://nrl.northumbria.ac.uk/id/eprint/30772

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