Antimicrobial peptides and wound healing: biological and therapeutic considerations

Mangoni, Maria Luisa, McDermott, Alison and Zasloff, Michael (2016) Antimicrobial peptides and wound healing: biological and therapeutic considerations. Experimental Dermatology, 25 (3). pp. 167-173. ISSN 0906-6705

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Official URL: https://doi.org/10.1111/exd.12929

Abstract

Repair of tissue wounds is a fundamental process to re-establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.

Item Type: Article
Uncontrolled Keywords: antibiotic resistance; antimicrobial peptide; frog skin; innate immunity; skin infections; wound healing
Subjects: B100 Anatomy, Physiology and Pathology
B900 Others in Subjects allied to Medicine
C100 Biology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 19 May 2017 15:20
Last Modified: 24 Oct 2017 11:23
URI: http://nrl.northumbria.ac.uk/id/eprint/30777

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