Role of host-defence peptides in eye diseases

Kolar, Satya and McDermott, Alison (2011) Role of host-defence peptides in eye diseases. Cellular and Molecular Life Sciences, 68 (13). pp. 2201-2213. ISSN 1420-682X

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Official URL: https://doi.org/10.1007/s00018-011-0713-7

Abstract

The eye and its associated tissues including the lacrimal system and lids have evolved several defence mechanisms to prevent microbial invasion. Included among this armory are several host-defence peptides. These multifunctional molecules are being studied not only for their endogenous antimicrobial properties but also for their potential therapeutic effects. Here the current knowledge of host-defence peptide expression in the eye will be summarised. The role of these peptides in eye disease will be discussed with the primary focus being on infectious keratitis, inflammatory conditions including dry eye and wound healing. Finally the potential of using host-defence peptides and their mimetics/derivatives for the treatment and prevention of eye diseases is addressed.

Item Type: Article
Uncontrolled Keywords: Defensin, Cathelicidin, Keratitis, Dry eye, Contact lens
Subjects: B500 Ophthalmics
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 23 May 2017 14:00
Last Modified: 23 May 2017 14:00
URI: http://nrl.northumbria.ac.uk/id/eprint/30806

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