Elevated Nerve Growth Factor in Dry Eye Associated With Established Contact Lens Wear

Liu, Qiong, McDermott, Alison and Miller, William (2009) Elevated Nerve Growth Factor in Dry Eye Associated With Established Contact Lens Wear. Eye & Contact Lens: Science & Clinical Practice, 35 (5). pp. 232-237. ISSN 1542-2321

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Official URL: https://doi.org/10.1097/ICL.0b013e3181b3e87f

Abstract

Purpose: Nerve growth factor (NGF) has been shown to be upregulated in conditions, which damage corneal nerves and to relieve dry eye. How NGF changes in nerve injury induced by established contact lens wear is not clear. The purpose of this study was to measure the subepithelial nerve plexus and tear NGF and transforming growth factor (TGF)-β1 levels in patients with established contact lens associated with dry eye.

Methods: Non-contact lens wearers and subjects who had worn soft contact lenses for more than 1 year were recruited and were divided into three groups: (1) normal controls; (2) contact lens wearers without dry eye; (3) contact lens wearers with dry eye. Corneal sensitivity was measured with a Cochet-Bonnet aesthesiometer. Nerve density and branching in the subepithelial plexus were measured using in vivo confocal microscopy. Tear NGF and TGF-β1 levels were measured with an enzyme immuno assay.

Results: There was a statistically significant decrease of corneal sensitivity in contact lens wearers compared with normal controls. The nerve density in the subepithelial plexus of contact lens wearers with dry eye was 538.8 ± 39.3 μm/image (3.959 ± 0.28 pm/μm2) and 537.1 ± 30.9 μm/image (3.947 ± 0.27 pm/μm2) in those without dry eye. Both of these values were significantly (P=0.032) lower than in the normal controls (4.412 ± 0.21 pm/μm2). The concentration of tear NGF was increased in contact lens wearers with dry eye and was statistically significantly greater compared with contact lens wearers without dry eye. Transforming growth factor-β1 levels were found to increase one fold in contact lens associated dry eye, and were significantly correlated to NGF.

Conclusions: Corneal subepithelial nerve density was decreased in long-term contact lens wear but this change was not significantly correlated with tear film NGF concentration. Tear film NGF levels were elevated in contact lens related dry eye, likely in response to anti-inflammatory factors such as TGF-β1.

Item Type: Article
Uncontrolled Keywords: Nerve growth factor, Contact lens, Dry eye, Inflammation
Subjects: B500 Ophthalmics
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 23 May 2017 14:26
Last Modified: 23 May 2017 14:26
URI: http://nrl.northumbria.ac.uk/id/eprint/30811

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