The effect of age on the relationship between cardiac and vascular function

Houghton, David, Jones, Thomas, Cassidy, Sophie, Siervo, Mario, MacGowan, Guy, Trenell, Michael and Jakovljevic, Djordje (2016) The effect of age on the relationship between cardiac and vascular function. Mechanisms of Ageing and Development, 153. pp. 1-6. ISSN 0047-6374

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Official URL: https://doi.org/10.1016/j.mad.2015.11.001

Abstract

Age-related changes in cardiac and vascular function are associated with increased risk of cardiovascular mortality and morbidity. The aim of the present study was to define the effect of age on the relationship between cardiac and vascular function. Haemodynamic and gas exchange measurements were performed at rest and peak exercise in healthy individuals. Augmentation index was measured at rest. Cardiac power output, a measure of overall cardiac function, was calculated as the product of cardiac output and mean arterial blood pressure. Augmentation index was significantly higher in older than younger participants (27.7 ± 10.1 vs. 2.5 ± 10.1%, P < 0.01). Older people demonstrated significantly higher stroke volume and mean arterial blood pressure (P < 0.05), but lower heart rate (145 ± 13 vs. 172 ± 10 beats/min, P < 0.01) and peak oxygen consumption (22.5 ± 5.2 vs. 41.2 ± 8.4 ml/kg/min, P < 0.01). There was a significant negative relationship between augmentation index and peak exercise cardiac power output (r = −0.73, P = 0.02) and cardiac output (r = −0.69, P = 0.03) in older participants. Older people maintain maximal cardiac function due to increased stroke volume. Vascular function is a strong predictor of overall cardiac function in older but in not younger people.

Item Type: Article
Uncontrolled Keywords: Ageing; Cardiac function; Vascular function; Exercise test
Subjects: B100 Anatomy, Physiology and Pathology
C600 Sports Science
Department: Faculties > Health and Life Sciences > School of Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Paul Burns
Date Deposited: 08 Jun 2017 15:02
Last Modified: 08 Jun 2017 16:45
URI: http://nrl.northumbria.ac.uk/id/eprint/30998

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