The repeatability of the abbreviated (4‑h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise

O'Doherty, Alasdair, Sathyapalan, Thozhukat, Rigby, Alan, Ingle, Lee and Carroll, Sean (2016) The repeatability of the abbreviated (4‑h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise. European Journal of Nutrition. ISSN 1436-6207 (In Press)

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Official URL: https://dx.doi.org/10.1007/s00394-016-1320-z

Abstract

PURPOSE:
The Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention before OFTT reduces the TAG response, but the repeatability of this effect is unknown. The aim of this study was to determine the repeatability of the abbreviated 4-h OFTT with and without immediate prior aerobic exercise.

METHODS:
On four separate days, healthy adult male participants underwent two 4-h OFTT (n = 10) and another two 4-h OFTT with 1-h of standardised moderate intensity aerobic exercise performed immediately before meal ingestion (n = 11). The OFTT meal composition included 75.4 g total fat, 21.7 g carbohydrate and 13.7 g protein. Venous blood was sampled at baseline and hourly up to 4 h after the OFTT meal ingestion, and TAG area under the curve (AUC) was calculated.

RESULTS:
Nonparametric Bland-Altman analysis of 4-h TAG AUC revealed that 9 of 10 repeat measurements fell within ±15 % of the median TAG AUC for the OFTT. By contrast, two of 11 repeat measurements fell within ±15 % of the median TAG AUC for the OFTT undertaken with 1-h prior aerobic exercise.

CONCLUSIONS:
The 4-h OFTT is a repeatable test of postprandial TAG responses in healthy men. However, aerobic exercise performed immediately before OFTT considerably increases the variability of TAG AUC. These findings have implications for interpretation of research studies investigating exercise intervention performed immediately before OFTT. Future studies should also investigate the repeatability of exercise performed 8-24 h before OFTT.

Item Type: Article
Uncontrolled Keywords: OFTT, Postprandial metabolism, Acute exercise, Lipids, Repeatability
Subjects: B100 Anatomy, Physiology and Pathology
B400 Nutrition
B900 Others in Subjects allied to Medicine
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Alasdair O'doherty
Date Deposited: 21 Jul 2017 15:36
Last Modified: 28 Oct 2017 16:40
URI: http://nrl.northumbria.ac.uk/id/eprint/31384

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