Multiscale adaptive analysis of circadian rhythms and intradaily variability: Application to actigraphy time series in acute insomnia subjects

Yamazaki, Shin, Fossion, Ruben, Rivera, Ana Leonor, Toledo-Roy, Juan C., Ellis, Jason and Angelova, Maia (2017) Multiscale adaptive analysis of circadian rhythms and intradaily variability: Application to actigraphy time series in acute insomnia subjects. PLoS ONE, 12 (7). e0181762. ISSN 1932-6203

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Official URL: https://doi.org/10.1371/journal.pone.0181762

Abstract

Circadian rhythms become less dominant and less regular with chronic-degenerative disease, such that to accurately assess these pathological conditions it is important to quantify not only periodic characteristics but also more irregular aspects of the corresponding time series. Novel data-adaptive techniques, such as singular spectrum analysis (SSA), allow for the decomposition of experimental time series, in a model-free way, into a trend, quasiperiodic components and noise fluctuations. We compared SSA with the traditional techniques of cosinor analysis and intradaily variability using 1-week continuous actigraphy data in young adults with acute insomnia and healthy age-matched controls. The findings suggest a small but significant delay in circadian components in the subjects with acute insomnia, i.e. a larger acrophase, and alterations in the day-to-day variability of acrophase and amplitude. The power of the ultradian components follows a fractal 1/f power law for controls, whereas for those with acute insomnia this power law breaks down because of an increased variability at the 90min time scale, reminiscent of Kleitman’s basic rest-activity (BRAC) cycles. This suggests that for healthy sleepers attention and activity can be sustained at whatever time scale required by circumstances, whereas for those with acute insomnia this capacity may be impaired and these individuals need to rest or switch activities in order to stay focused. Traditional methods of circadian rhythm analysis are unable to detect the more subtle effects of day-to-day variability and ultradian rhythm fragmentation at the specific 90min time scale.

Item Type: Article
Subjects: B900 Others in Subjects allied to Medicine
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Related URLs:
Depositing User: Paul Burns
Date Deposited: 07 Aug 2017 11:02
Last Modified: 27 Oct 2017 19:32
URI: http://nrl.northumbria.ac.uk/id/eprint/31553

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