Fluostatins C~E, novel members of the fluostatin family produced by Streptomyces sp. Acta 1383

Baur, Stefanie, Niehaus, Jörg, Karagouni, Amalia, Katsifas, Efstathios, Chalkou, Kalliopi, Maintanis, Christos, Jones, Amanda, Goodfellow, Michael, Ward, Alan, Beil, Winfried, Schneider, Kathrin, Süssmuth, Roderich and Fiedler, Hans-Peter (2006) Fluostatins C~E, novel members of the fluostatin family produced by Streptomyces sp. Acta 1383. Journal of Antibiotics, 59. pp. 293-297. ISSN 0021-8820

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Official URL: http://dx.doi.org/10.1038/ja.2006.41

Abstract

Three new members of the fluostatin family, fluostatins CE, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.

Item Type: Article
Uncontrolled Keywords: streptomyces, fermentation
Subjects: B200 Pharmacology, Toxicology and Pharmacy
C500 Microbiology
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrints Services
Date Deposited: 29 May 2009 13:19
Last Modified: 10 Aug 2015 11:49
URI: http://nrl.northumbria.ac.uk/id/eprint/3218

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