Inflammasome lights up in systemic sclerosis

Henderson, John and O'Reilly, Steven (2017) Inflammasome lights up in systemic sclerosis. Arthritis Research & Therapy, 19 (1). p. 205. ISSN 1478-6362

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Abstract

Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.

Item Type: Article
Uncontrolled Keywords: Sclerosis, Fibrosis, Inflammasome, microRNA, Epigenetics, Interleukin-1, Caspase-1, MCC950
Subjects: C400 Genetics
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 05 Oct 2017 13:29
Last Modified: 28 Oct 2017 14:01
URI: http://nrl.northumbria.ac.uk/id/eprint/32204

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