Vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy: a feasibility randomised controlled trial

Banerjee, Srijit, Manley, Kate, Shaw, Barnabas, Lewis, Liane, Cucato, Gabriel, Mills, Robert, Rochester, Mark, Clark, Allan and Saxton, John (2017) Vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy: a feasibility randomised controlled trial. Supportive Care in Cancer. ISSN 0941-4355

[img] Text (Full text)
Banerjee et al - Vigorous intensity aerobic interval exercise in bladder cancer patients AAM.docx - Accepted Version
Restricted to Repository staff only until 27 November 2018.

Download (145kB)
Official URL: https://doi.org/10.1007/s00520-017-3991-2

Abstract

Purpose:
Strategies to improve pre-operative cardiopulmonary fitness could positively impact recovery after surgery. This study investigated the feasibility of vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy (RC).

Methods:
A total of 60 patients were randomised (1:1) to exercise or control following a cardiopulmonary exercise test (CPET). The exercise group was offered twice-weekly pre-operative supervised vigorous intensity aerobic interval exercise in addition to standard treatment. The controls received standard treatment only. A repeat CPET was undertaken before surgery and post-operative recovery outcomes were recorded.

Results:
Over half of the 112 eligible patients approached in the clinic were recruited to the study (53.5%), with recruited patients attending a median of 8 (range 1–10) exercise sessions over a pre-operative period of 3–6 weeks. Improvements in peak values of oxygen pulse (P = 0.001), minute ventilation (P = 0.002) and power output (P < 0.001) were observed at the follow-up CPET in the exercise group versus controls and there were no adverse events. Although this feasibility study was not powered to detect changes in post-operative recovery outcomes, there were marginal (non-significant) differences in favour of the exercise group in post-operative Clavien-Dindo score and need for high dependency unit inotropic support.

Conclusions:
Bladder cancer patients respond well to pre-surgical aerobic interval exercise, and the improvements in cardiopulmonary fitness variables could have important implications for post-operative recuperation after RC. These findings provide a strong foundation for an adequately powered randomised controlled trial.

Item Type: Article
Uncontrolled Keywords: Pre-operative care, Exercise, Urinary bladder neoplasms
Subjects: A100 Pre-clinical Medicine
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Paul Burns
Date Deposited: 30 Nov 2017 09:47
Last Modified: 30 Nov 2017 10:49
URI: http://nrl.northumbria.ac.uk/id/eprint/32697

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics


Policies: NRL Policies | NRL University Deposit Policy | NRL Deposit Licence