Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD

Bessa, Vasiliki, Loukides, Stelios, Hillas, Georgios, Delimpoura, Vasiliki, Camargo Madeira Simoes, Davina, Kontogianni, Konstantina, Papiris, Spyros, Kostikas, Konstantinos, Alchanatis, Manos and Bakakos, Petros (2012) Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD. Cytokine, 58 (3). pp. 455-460. ISSN 1043-4666

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Official URL: https://doi.org/10.1016/j.cyto.2012.03.007


Pathological features of chronic obstructive pulmonary disease (COPD) include lung vascular remodeling and angiogenesis. Angiopoietin-1 (Ang-1), is an essential mediator of angiogenesis by establishing vascular integrity, whereas angiopoietin-2 (Ang-2) acts as its natural inhibitor. We determined the levels of angiopoietins in sputum supernatants of patients with COPD and investigated their possible association with mediators and cells involved in the inflammatory and remodeling process.

Fifty-nine patients with COPD, 25 healthy smokers and 20 healthy non-smokers were studied. All subjects underwent lung function tests, sputum induction for cell count identification and Ang-1, Ang-2, VEGF, TGF-β1, MMP-2, LTB4, IL-8, albumin measurement in sputum supernatants. Airway vascular permeability (AVP) index was also assessed.

Ang-2 levels were significantly higher in patients with COPD compared to healthy smokers and healthy non-smokers [median, interquartile ranges pg/ml, 267 (147–367) vs. 112 (67–171) and 98 (95–107), respectively; p < 0.001]. Regression analysis showed a significant association between Ang-2 levels and AVP index, VEGF, IL-8 and MMP-2 levels in COPD, the strongest being with VEGF.

Our results indicate that induced sputum Ang-2 levels are higher in COPD compared to healthy smokers and healthy non-smokers. Moreover, Ang-2 is associated with AVP, IL-8, MMP-2, and VEGF, indicating a possible role for Ang-2 in the pathogenesis of the disease.

Item Type: Article
Uncontrolled Keywords: Chronic obstructive pulmonary disease, Induced sputum, Angiogenesis, Inflammation
Subjects: B100 Anatomy, Physiology and Pathology
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Becky Skoyles
Date Deposited: 15 Dec 2017 11:00
Last Modified: 15 Dec 2017 11:00
URI: http://nrl.northumbria.ac.uk/id/eprint/32867

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