Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease

Alissafi, Themis, Kourepini, Evangelia, Camargo Madeira Simoes, Davina, Paschalidis, Nikolaos, Aggelakopoulou, Maria, Sparwasser, Tim, Boon, Louis, Hammad, Hamida, Lambrecht, Bart and Panoutsakopoulou, Vily (2018) Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease. The Journal of Immunology, 200 (4). pp. 1270-1282. ISSN 0022-1767

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Official URL: https://doi.org/10.4049/jimmunol.1701345

Abstract

In the context of inflammation, osteopontin (Opn) is known to promote effector responses, facilitating a proinflammatory environment; however, its role during antigenic tolerance induction is unknown. Using a mouse model of asthma, we investigated the role of Opn during antigenic tolerance induction and its effects on associated regulatory cellular populations prior to disease initiation. Our experiments demonstrate that Opn drives protective antigenic tolerance by inducing accumulation of IFN-β–producing plasmacytoid dendritic cells, as well as regulatory T cells, in mediastinal lymph nodes. We also show that, in the absence of TLR triggers, recombinant Opn, and particularly its SLAYGLR motif, directly induces IFN-β expression in Ag-primed plasmacytoid dendritic cells, which renders them extra protective against induction of allergic airway disease upon transfer into recipient mice. Lastly, we show that blockade of type I IFNR prevents antigenic tolerance induction against experimental allergic asthma. Overall, we unveil a new role for Opn in setting up a tolerogenic milieu boosting antigenic tolerance induction, thus leading to prevention of allergic airway inflammation. Our results provide insight for the future design of immunotherapies against allergic asthma.

Item Type: Article
Subjects: B100 Anatomy, Physiology and Pathology
B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Becky Skoyles
Date Deposited: 15 Jan 2018 11:43
Last Modified: 12 Jan 2019 08:00
URI: http://nrl.northumbria.ac.uk/id/eprint/33104

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