Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer

Lawler, Mark, Alsina, Deborah, Adams, Richard A., Anderson, Annie S., Brown, Gina, Fearnhead, Nicola S., Fenwick, Stephen W., Halloran, Stephen P., Hochhauser, Daniel, Hull, Mark A., Koelzer, Viktor H., McNair, Angus G. K., Monahan, Kevin J., Näthke, Inke, Norton, Christine, Novelli, Marco R., Steele, Robert J. C., Thomas, Anne L., Wilde, Lisa M., Wilson, Richard H. and Tomlinson, Ian (2018) Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. Gut, 67 (1). pp. 179-193. ISSN 0017-5749

[img]
Preview
Text (Full text)
Lawler et al - Critical research gaps and recommendations for improved outcomes in colorectal cancer.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial 4.0.

Download (762kB) | Preview
Official URL: https://doi.org/10.1136/gutjnl-2017-315333

Abstract

Objective:
Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes.

Design:
RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants.

Results:
Fifteen critical RGs are summarised below: RG1: Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2: Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; RG3: Pressing need for prevention trials; RG4: Lack of integration of different prevention approaches; RG5: Lack of optimal strategies for CRC screening; RG6: Lack of effective triage systems for invasive investigations; RG7: Imprecise pathological assessment of CRC; RG8: Lack of qualified personnel in genomics, data sciences and digital pathology; RG9: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10: Need for novel technologies/interventions to improve curative outcomes; RG11: Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12: Lack of reliable biomarkers to guide stage IV treatment; RG13: Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; RG14: Lack of coordination of CRC research/funding; RG15: Lack of effective communication between relevant stakeholders.

Conclusion:
Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.

Item Type: Article
Subjects: A300 Clinical Medicine
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Paul Burns
Date Deposited: 18 Jan 2018 09:40
Last Modified: 28 Feb 2019 15:32
URI: http://nrl.northumbria.ac.uk/id/eprint/33142

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics


Policies: NRL Policies | NRL University Deposit Policy | NRL Deposit Licence