A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus on-route to a key intermediate in the synthesis of GSK2248761A

Ironmonger, Alan, Shipton, Mark, Slater, Fiona, Szeto, Pete, Unthank, Matthew, Alexandre, François-René, Caillet, Catherine and Dousson, Cyril B. (2018) A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus on-route to a key intermediate in the synthesis of GSK2248761A. Tetrahedron Letters, 59 (22). pp. 2154-2156. ISSN 0040-4039

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Official URL: http://dx.doi.org/10.1016/j.tetlet.2018.04.018

Abstract

A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available chiral auxiliary. The practicality of this transformation is demonstrated on a multi-gram scale.

Item Type: Article
Uncontrolled Keywords: Asymmetric synthesis; Chiral phosphorus; Dynamic kinetic resolution; GSK2248761A; Phenylglycine methyl ester
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 04 Jun 2018 09:34
Last Modified: 11 Oct 2019 08:16
URI: http://nrl.northumbria.ac.uk/id/eprint/34458

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