Dietary intake of anthocyanins and risk of cardiovascular disease: a systematic review and meta-analysis of prospective cohort studies

Kimble, Rachel, Keane, Karen, Lodge, John and Howatson, Glyn (2020) Dietary intake of anthocyanins and risk of cardiovascular disease: a systematic review and meta-analysis of prospective cohort studies. Critical Reviews in Food Science and Nutrition, 59 (18). pp. 3032-3043. ISSN 1040-8398

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Accepted version_Anthocyanin systematic review and meta-analysis manuscript.pdf - Accepted Version

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Official URL: https://doi.org/10.1080/10408398.2018.1509835

Abstract

Accumulating evidence suggests flavonoid intake is associated with reduced risk of non-communicable diseases. We aimed to systematically determine and quantify the potential association between dietary anthocyanin intake and risk of cardiovascular diseases (CVD). A systematic literature search of studies reporting anthocyanin intake and risk of fatal or nonfatal CVD was performed using SCOPUS, MEDLINE, CINAHL and Cochrane Library. The relative risk (RR) or hazard ratio (HR) of highest category of anthocyanin foods were pooled in a random-effects meta-analysis. Subgroup analysis were conducted to determine possible sources of heterogeneity. The meta-analysis suggested intake of dietary anthocyanins and reduced risk of CHD (RR = 0.91, 95% CI: 0.83, 0.99; I2 = 12.0, Ph = 0.337) and CVD mortality (RR = 0.92, 95% CI: 0.87, 0.97; I2 = 0.0, Ph = 0.584). However, there was no relationship between the intake of these compounds and reduced risk of MI, stroke or total CVD. Subgroup analysis determined reduced risk of CHD and CVD mortality was more prominent for anthocyanidin intake, as opposed to anthocyanin or berries. Our systematic review and meta-analysis provides evidence that anthocyanins, specifically anthocyanidins, reduce the risk of CHD and CVD mortality. Further randomised controlled trials on anthocyanin intake and CVD risk factors are needed to support these findings.

Item Type: Article
Uncontrolled Keywords: Flavonoids, Cardiovascular disease, Anthocyanidins, Epidemiology
Subjects: B400 Nutrition
Department: Faculties > Health and Life Sciences > Applied Sciences
Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Becky Skoyles
Date Deposited: 09 Aug 2018 14:12
Last Modified: 22 Jan 2020 11:15
URI: http://nrl.northumbria.ac.uk/id/eprint/35244

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