Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

Toscani, Anita, Risi, Caterina, Black, Gary, Brown, Nicola, Shaaban, Ali, Turner, Nicholas J. and Castagnolo, Daniele (2018) Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines. ACS Catalysis, 8 (9). pp. 8781-8787. ISSN 2155-5435

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Official URL: https://doi.org/10.1021/acscatal.8b02386

Abstract

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

Item Type: Article
Uncontrolled Keywords: aromatization; biocatalysis; in situ NMR; MAO-N; pyridine; tetrahydropyridine
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 28 Nov 2018 08:51
Last Modified: 13 May 2019 16:05
URI: http://nrl.northumbria.ac.uk/id/eprint/36940

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