Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

Hohmann, Claudia, Schneider, Kathrin, Bruntner, Christina, Irran, Elisabeth, Nicholson, Graeme, Bull, Alan, Jones, Amanda, Brown, Roselyn, Stach, James, Goodfellow, Michael, Beil, Winfried, Krämer, Marco, Imhoff, Johannes, Süssmuth, Roderich and Fiedler, Hans-Peter (2009) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937. Journal of Antibiotics, 62. pp. 99-104. ISSN 0021-8820

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Official URL: http://dx.doi.org/10.1038/ja.2008.24

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase

Item Type: Article
Subjects: C100 Biology
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 01 Jun 2009 13:20
Last Modified: 16 Mar 2016 13:47
URI: http://nrl.northumbria.ac.uk/id/eprint/3731

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