Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Commane, Daniel, Arasaradnam, Ramesh, Mills, Sarah, Mathers, John and Bradburn, Mike (2009) Diet, ageing and genetic factors in the pathogenesis of diverticular disease. World Journal of Gastroenterology, 15 (20). pp. 2479-2488. ISSN 1007-9327

[img]
Preview
Text (Full text)
Commane et al - Diet, ageing and genetic factors in the pathogenesis of diverticular disease OA.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial 4.0.

Download (802kB) | Preview
Official URL: http://dx.doi.org/10.3748/wjg.15.2479

Abstract

Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressure-induced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.

Item Type: Article
Uncontrolled Keywords: Diverticular disease; Dietary factors; Genetics; Colon; Inflammation
Subjects: B100 Anatomy, Physiology and Pathology
B400 Nutrition
B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 14 Jan 2019 17:18
Last Modified: 08 Feb 2019 16:00
URI: http://nrl.northumbria.ac.uk/id/eprint/37577

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics


Policies: NRL Policies | NRL University Deposit Policy | NRL Deposit Licence