The immunopathogenesis of fibrosis in systemic sclerosis

Brown, Melvyn and O'Reilly, Steven (2019) The immunopathogenesis of fibrosis in systemic sclerosis. Clinical & Experimental Immunology, 195 (3). pp. 310-321. ISSN 0009-9104

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Official URL: https://doi.org/10.1111/cei.13238

Abstract

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction in SSc is characterized by the activation and recruitment of immune cells and the production of autoantibodies and cytokines. How immune abnormalities link the fibrosis and vasculopathy in SSc is poorly understood. A plethora of immune cell types are implicated in the immunopathogenesis of SSc, including T cells, B cells, dendritic cells, mast cells and macrophages. How these different cell types interact to contribute to SSc is complicated, and can involve cell‐to‐cell interactions and communication via cytokines, including transforming growth factor (TGF)‐β, interleukin (IL)‐6 and IL‐4. We will attempt to review significant and recent research demonstrating the importance of immune cell regulation in the immunopathogenesis of SSc with a particular focus on fibrosis.

Item Type: Article
Uncontrolled Keywords: arthritis (including rheumatoid arthritis), B cells, T cells, Toll-like receptors (TLRs)
Subjects: B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 01 Feb 2019 11:47
Last Modified: 28 Feb 2019 15:54
URI: http://nrl.northumbria.ac.uk/id/eprint/37847

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