Managing fatigue in patients with primary Sjögren's syndrome

Miyamoto, Samira, Lendrem, Dennis, Ng, Wan-Fai, Hackett, Kate and Valim, Valeria (2019) Managing fatigue in patients with primary Sjögren's syndrome. Open Access Rheumatology: Research and Reviews, 2019. pp. 77-88. ISSN 1179-156X

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Official URL: https://doi.org/10.2147/OARRR.S167990

Abstract

Primary Sjögren’s syndrome (pSS) patients identify fatigue as their most important symptom and the one most difficult to cope with, but there are still many challenges and few solutions to manage this debilitating symptom. Promising pharmacological treatments, such as rituximab, have failed in more stringent tests including randomized controlled trials (RCT) and meta-analysis. While non-pharmacological interventions may be safer, less costly, and address other common comorbidities, to date only aerobic exercise seems to be effective at reducing fatigue in pSS. All interventions, pharmacological or not, need to be tested in high-quality RCTs. The aim of this review is to provide an overview of fatigue management in pSS and discuss potential opportunities for future research.

Item Type: Article
Uncontrolled Keywords: primary Sjögren’s syndrome, fatigue, treatment, review
Subjects: B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Social Work, Education and Community Wellbeing
Depositing User: Paul Burns
Date Deposited: 04 Mar 2019 17:47
Last Modified: 31 May 2019 03:30
URI: http://nrl.northumbria.ac.uk/id/eprint/38290

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