Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity

Elliott, Luke D., Knowles, Jonathan P., Koovits, Paul J., Maskill, Katie G., Ralph, Michael J., Lejeune, Guillaume, Edwards, Lee J., Robinson, Richard I., Clemens, Ian R., Cox, Brian, Pascoe, David D., Koch, Guido, Eberle, Martin, Berry, Malcolm B. and Booker-Milburn, Kevin I. (2014) Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity. Chemistry: A European Journal, 20 (46). pp. 15226-15232. ISSN 0947-6539

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Official URL: https://doi.org/10.1002/chem.201404347

Abstract

The use of flow photochemistry and its apparent superiority over batch has been reported by a number of groups in recent years. To rigorously determine whether flow does indeed have an advantage over batch, a broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared. Surprisingly, yields were essentially identical in all comparative cases. Even more revealing was the observation that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched. Those with a single layer of fluorinated ethylene propylene (FEP) had an average productivity 20 % lower than that of batch, whereas three‐layer reactors were 20 % more productive. Finally, the utility of flow chemistry was demonstrated in the scale‐up of the ring‐opening reaction of a potentially explosive [1.1.1] propellane with butane‐2,3‐dione.

Item Type: Article
Uncontrolled Keywords: batch reactors, cycloaddition, flow photochemistry, rearrangement scale‐up
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 15 Mar 2019 16:00
Last Modified: 15 Mar 2019 16:00
URI: http://nrl.northumbria.ac.uk/id/eprint/38429

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