Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements

Bowerbank, Samantha, Carlin, Michelle and Dean, John (2019) Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements. Separations, 6 (1). p. 18. ISSN 2297-8739

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Official URL: http://dx.doi.org/10.3390/separations6010018

Abstract

A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37 °C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single- and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.

Item Type: Article
Uncontrolled Keywords: thyroid, dissolution, liquid chromatography-mass spectrometry
Subjects: B800 Medical Technology
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 04 Apr 2019 10:57
Last Modified: 11 Oct 2019 07:53
URI: http://nrl.northumbria.ac.uk/id/eprint/38743

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