Probiotics in Extraintestinal Diseases: Current Trends and New Directions

Kiousi, Despoina, Karapetsas, Athanasios, Karolidou, Kyriaki, Panagiotidis, Mihalis, Pappa, Aglaia and Galanis, Alex (2019) Probiotics in Extraintestinal Diseases: Current Trends and New Directions. Nutrients, 11 (4). pp. 1-26. ISSN 2072-6643

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Official URL: http://doi.org/10.3390/nu11040788

Abstract

Probiotics are defined as live microorganisms that when administered in adequate amounts confer a health benefit to the host. Their positive supplementation outcomes on several gastrointestinal disorders are well defined. Nevertheless, their actions are not limited to the gut, but may also impart their beneficial effects at distant sites and organs. In this regard, in this review article we: (i) comprehensively describe the main mechanisms of action of probiotics at distant sites, including bones, skin, and brain; (ii) critically present their therapeutic potential against bone, skin, and neuronal diseases (e.g., osteoporosis, non-healing wounds and autoimmune skin illnesses, mood, behavior, memory, and cognitive impairments); (iii) address the current gaps in the preclinical and clinical research; and (iv) indicate new research directions and suggest future investigations.

Item Type: Article
Uncontrolled Keywords: probiotics; gastrointestinal; skin; bone; neuronal disease; microbiota
Subjects: C500 Microbiology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 04 Apr 2019 13:51
Last Modified: 11 Oct 2019 08:02
URI: http://nrl.northumbria.ac.uk/id/eprint/38757

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