Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient

Ramdhan, Nikhil Doorvesh, Blom, Jochen, Sutcliffe, Iain, Pereira-Ribeiro, Paula Marcele Afonso, Santos, Cintia Silva, Mattos-Guaraldi, Ana Luiza, Burkovski, Andreas and Sangal, Vartul (2019) Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient. New Microbes and New Infections, 30. p. 100544. ISSN 2052-2975

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Official URL: https://doi.org/10.1016/j.nmni.2019.100544

Abstract

The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.

Item Type: Article
Uncontrolled Keywords: Adenoid cystic carcinoma, Corynebacterium diphtheriae, invasive infection, nontoxigenic, virulence
Subjects: A300 Clinical Medicine
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 29 Apr 2019 15:02
Last Modified: 11 Oct 2019 08:36
URI: http://nrl.northumbria.ac.uk/id/eprint/39099

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