Targeting the TLR4–MD2 axis in systemic sclerosis

O'Reilly, Steven and van Laar, Jacob M. (2018) Targeting the TLR4–MD2 axis in systemic sclerosis. Nature Reviews Rheumatology, 14 (10). pp. 564-566. ISSN 1759-4790

Full text not available from this repository. (Request a copy)
Official URL: https://doi.org/10.1038/s41584-018-0077-6

Abstract

Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.

Item Type: Article
Subjects: B200 Pharmacology, Toxicology and Pharmacy
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 02 May 2019 14:49
Last Modified: 01 Aug 2019 14:25
URI: http://nrl.northumbria.ac.uk/id/eprint/39157

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics


Policies: NRL Policies | NRL University Deposit Policy | NRL Deposit Licence