The key role of insomnia and sleep loss in the dysregulation of multiple systems involved in mood disorders: A proposed model

Palagini, Laura, Bastien, Celyne H., Marazziti, Donatella, Ellis, Jason and Riemann, Dieter (2019) The key role of insomnia and sleep loss in the dysregulation of multiple systems involved in mood disorders: A proposed model. Journal of Sleep Research. e12841. ISSN 0962-1105 (In Press)

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Official URL: https://doi.org/10.1111/jsr.12841

Abstract

Mood disorders are amongst the most prevalent and severe disorders worldwide, with a tendency to be recurrent and disabling. Although multiple mechanisms have been hypothesized to be involved in their pathogenesis, just a few integrative theoretical frameworks have been proposed and have yet to integrate comprehensively all available findings. As such, a comprehensive framework would be quite useful from a clinical and therapeutic point of view in order to identify elements to evaluate and target in the clinical practice. Because conditions of sleep loss, which include reduced sleep duration and insomnia, are constant alterations in mood disorders, the aim of this paper was to review the literature on their potential role in the pathogenesis of mood disorders and to propose a novel theoretical model. According to this hypothesis, sleep should be considered the main regulator of several systems and processes whose dysregulation is involved in the pathogenesis of mood disorders. The model may help explain why sleep disturbances are so strikingly linked to mood disorders, and underscores the need to evaluate, assess and target sleep disturbances in clinical practice, as a priority, in order to prevent and treat mood disorders.

Item Type: Article
Uncontrolled Keywords: circadian system, emotion regulation, insomnia, monoamine neurotransmission, mood disorders, neurobiological mechanisms, neuronal plasticity‐connectivity, sleep loss, stress‐inflammatory system
Subjects: C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Elena Carlaw
Date Deposited: 08 May 2019 09:13
Last Modified: 10 Oct 2019 19:16
URI: http://nrl.northumbria.ac.uk/id/eprint/39214

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