A two-phase cohort study of the sleep phenotype within primary Sjögren’s syndrome and its clinical correlates

Lewis, Ieuan, Hackett, Kate, Ng, Wan-Fai, Ellis, Jason and Newton, Julia L. (2019) A two-phase cohort study of the sleep phenotype within primary Sjögren’s syndrome and its clinical correlates. Clinical and Experimental Rheumatology. ISSN 0392-856X (In Press)

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Abstract

Objectives. To characterise the sleep profile of patients with Primary Sjögren’s syndrome (PSS) and its relationship between hyper-somnolence and other clinical parameters.

Methods. In phase one of the study, we utilised cross-sectional data on daytime hyper-somnolence from the United Kingdom Primary Sjögren’s Syndrome Registry (UKPSSR) cohort (n=857, female=92.7%). Phase two relied on clinical data from a cohort of patients (n=30) with PSS, utilising symptom assessment questionnaires and sleep diaries.

Results. Within the UKPSSR Daytime hyper-somnolence was prevalent (ESS, 8.2±5.1) amongst PSS patients with a positive correlation between daytime hypersomnolence and fatigue (Spearman’s rs = 0.42, p<0.0001). Amongst the clinical cohort, 100% of patients had problematic sleep. Participants with PSS awoke frequently (NWAK, 2.2±1.3), had difficulty in returning back to sleep (WASO, 59.9±50.2 min vs. normal of <30min) and a reduced sleep efficiency (SE, 65.7±18.5% vs. >85%). Fatigue (FIS, 82.4 ±33.5) and orthostatic symptoms (OGS, 6.7 ±3.7) remained high in these patients.

Conclusions. Sleep disturbances are a problem in PSS. Comprising of difficulty maintaining sleep, frequent awakenings throughout the night and difficulties in returning back to sleep. As such the total time in bed without sleep is much greater and sleep efficiency greatly reduced. These patients in addition have a high symptomatic burden possibly contributing to and/or contributed by poor and disordered sleep.

Item Type: Article
Uncontrolled Keywords: primary Sjögren’s syndrome, sleep, fatigue
Subjects: B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > Social Work, Education and Community Wellbeing
Depositing User: Paul Burns
Date Deposited: 05 Jun 2019 16:51
Last Modified: 05 Jun 2019 17:00
URI: http://nrl.northumbria.ac.uk/id/eprint/39515

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