Anticancer activity of a novel methylated analogue of L-mimosine against an in vitro model of human malignant melanoma

Kyriakou, Sotiris, Mitsiogianni, Melina, Mantso, Theodora, Cheung, William, Todryk, Stephen, Veuger, Stephany, Pappa, Algaia, Tetard, David and Panagiotidis, Mihalis (2019) Anticancer activity of a novel methylated analogue of L-mimosine against an in vitro model of human malignant melanoma. Investigational New Drugs. ISSN 0167-6997 (In Press)

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Official URL: https://doi.org/10.1007/s10637-019-00809-0

Abstract

The anticancer activity of a series of novel synthesized, hydroxypyridone-based metal chelators (analogues of L-mimosine) was evaluated in an in vitro model of melanoma consisting of malignant melanoma (A375), non-melanoma epidermoid carcinoma (A431) and immortalized non-malignant keratinocyte (HaCaT) cells. More specifically, we have demonstrated that the L-enantiomer of a methylated analogue of L-mimosine (compound 22) can exert a potent anticancer effect in A375 cells when compared to either A431 or HaCaT cells. Moreover, we have demonstrated that this analogue has the ability to i) promote increased generation of reactive oxygen species (ROS), ii) activate both intrinsic and extrinsic apoptosis and iii) induce perturbations in cell cycle growth arrest. Our data highlights the potential of compound 22 to act as a promising therapeutic agent against an in vitro model of human malignant melanoma.

Item Type: Article
Uncontrolled Keywords: Metal chelators, L-mimosine analogues, skin cancer, anticancer activity, melanoma
Subjects: B200 Pharmacology, Toxicology and Pharmacy
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 06 Jun 2019 10:29
Last Modified: 03 Jul 2019 11:45
URI: http://nrl.northumbria.ac.uk/id/eprint/39525

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