Mitochondrial Homeostasis and Cellular Senescence

Vasileiou, Panagiotis V.S., Evangelou, Konstantinos, Vlasis, Konstantinos, Fildisis, Georgios, Panagiotidis, Mihalis, Chronopoulos, Efstathios, Passias, Panagiotis-Georgios, Kouloukoussa, Mirsini, Gorgoulis, Vassilis G. and Havaki, Sophia (2019) Mitochondrial Homeostasis and Cellular Senescence. Cells, 8 (7). ISSN 2073-4409

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Official URL: http://dx.doi.org/10.3390/cells8070686

Abstract

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.

Item Type: Article
Uncontrolled Keywords: cellular senescence; mitochondria; mitostasis; mitochondrial dynamics
Subjects: C100 Biology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 08 Jul 2019 08:52
Last Modified: 11 Oct 2019 09:40
URI: http://nrl.northumbria.ac.uk/id/eprint/39887

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