Synthesis of pryridine and 2,2'-biprydine derivatives from the aza Diels-Alder reaction of substituted 1,2,4-triazines

Stanforth, Stephen, Tarbit, Brian and Watson, Michael (2004) Synthesis of pryridine and 2,2'-biprydine derivatives from the aza Diels-Alder reaction of substituted 1,2,4-triazines. Tetrahedron, 60 (40). pp. 8893-8897. ISSN 0040-4020

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Official URL: http://dx.doi.org/10.1016/j.tet.2004.07.024

Abstract

Amidrazone 1a and the tricarbonyl derivatives 2b–d reacted in boiling ethanol in the presence of 2,5-norbornadiene 5 giving the pyridine derivatives 6b–d respectively (59–72%) and in the presence of 2,3-dihydrofuran 7 yielding the lactones 10b–d (39–44%). The 2,2′-bipyridine derivatives 6e–g were similarly obtained in good yield (81–87%) from the reaction of amidrazone 1b and tricarbonyl derivatives 2b–d in the presence of 2,5-norbornadiene 5.

Item Type: Article
Additional Information: Output from industrially sponsored PhD collaboration (Seal Sands Chemicals). Some of this work has been commercialised via sponsor. The paper describes the synthesis of potential building blocks for pharmaceutical and agrochemical research; presented as an Invited Lecture at the Anglo-Italian Heterocyclic Conference, Harrogate (2006).
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrints Services
Date Deposited: 07 Jan 2009 14:11
Last Modified: 31 Mar 2016 10:16
URI: http://nrl.northumbria.ac.uk/id/eprint/402

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