DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukaemia

Langie, Sabine, Timms, Jessica, De Boever, Patrick and Mckay, Jill (2019) DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukaemia. Epigenomics, 11 (13). pp. 1519-1537. ISSN 1750-1911

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Official URL: https://doi.org/10.2217/epi-2019-0052

Abstract

Aims: The hygiene hypothesis states lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukaemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to infection. We investigated if aberrant methylation may be in common between these diseases and associated with infection.

Methods: RA and ALL disease-associated methylation signatures were compared and related to exposure-to-infection-signatures.

Results: A significant number of genes overlapped between RA and ALL signatures (p=0.0019). Significant overlaps were observed between exposure-to-infection signatures and disease-associated signatures.

Conclusion: DNA methylation may be a mediating mechanism through which the hygiene hypothesis is associated with RA and ALL risk.

Item Type: Article
Uncontrolled Keywords: epigenetics, allergy, DNA methylation, childhood acute lymphoblastic leukaemia, hygiene hypothesis, infection, exposure, proxy, day care, cold symptoms
Subjects: B900 Others in Subjects allied to Medicine
C400 Genetics
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 06 Sep 2019 16:31
Last Modified: 07 Nov 2019 10:45
URI: http://nrl.northumbria.ac.uk/id/eprint/40569

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