Pathways to cellular supremacy in biocomputing

Grozinger, Lewis, Amos, Martyn, Gorochowski, Thomas E., Carbonell, Pablo, Oyarzún, Diego A., Stoof, Ruud, Fellermann, Harold, Zuliani, Paolo, Tas, Huseyin and Goñi-Moreno, Angel (2019) Pathways to cellular supremacy in biocomputing. Nature Communications, 10 (1). ISSN 2041-1723

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Official URL: http://dx.doi.org/10.1038/s41467-019-13232-z

Abstract

Synthetic biology uses living cells as the substrate for performing human-defined computations. Many current implementations of cellular computing are based on the “genetic circuit” metaphor, an approximation of the operation of silicon-based computers. Although this conceptual mapping has been relatively successful, we argue that it fundamentally limits the types of computation that may be engineered inside the cell, and fails to exploit the rich and diverse functionality available in natural living systems. We propose the notion of “cellular supremacy” to focus attention on domains in which biocomputing might offer superior performance over traditional computers. We consider potential pathways toward cellular supremacy, and suggest application areas in which it may be found.

Item Type: Article
Subjects: C100 Biology
Department: Faculties > Engineering and Environment > Computer and Information Sciences
Depositing User: Ay Okpokam
Date Deposited: 21 Nov 2019 13:21
Last Modified: 21 Nov 2019 13:30
URI: http://nrl.northumbria.ac.uk/id/eprint/41564

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