A natural immunization process prevents malaria

Todryk, Stephen (2010) A natural immunization process prevents malaria. Trends in Parasitology, 26 (5). pp. 219-221. ISSN 1471-4922

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Official URL: http://dx.doi.org/10.1016/j.pt.2010.02.003

Abstract

Reproducing the poorly understood naturally acquired immunity to malaria that develops in the majority of individuals in malaria-endemic regions will reduce mortality in at-risk children. A paper by Roestenberg et al. [1] addresses this issue experimentally by describing the generation of sterilizing protective immunity against Plasmodium falciparum in malaria-naïve volunteers though controlled infection: a defined number of infectious mosquito bites with concurrent drug treatment. Measurable markers of protection were malaria-specific effector T cells simultaneously secreting IFNγ, IL-2 and TNFα, and, to a lesser degree, antibodies. Such responses may be key objectives for efficacious vaccination or intermittent preventive drug regimens.

Item Type: Article
Uncontrolled Keywords: immunity, malaria, T cells
Subjects: B900 Others in Subjects allied to Medicine
C900 Others in Biological Sciences
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Ay Okpokam
Date Deposited: 15 Dec 2011 15:55
Last Modified: 10 Aug 2015 11:41
URI: http://nrl.northumbria.ac.uk/id/eprint/4183

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