A link between transcription fidelity and pausing in vivo

Gamba, Pamela, James, Katherine and Zenkin, Nikolay (2017) A link between transcription fidelity and pausing in vivo. Transcription, 8 (2). pp. 99-105. ISSN 2154-1264

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Official URL: https://doi.org/10.1080/21541264.2016.1274812

Abstract

Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

Item Type: Article
Uncontrolled Keywords: Collisions of transcription with replication, fidelity, Gre, misincorporation, pausing, proofreading, TFIIS, transcription
Subjects: C400 Genetics
C500 Microbiology
C900 Others in Biological Sciences
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: John Coen
Date Deposited: 09 Mar 2020 09:59
Last Modified: 09 Mar 2020 10:00
URI: http://nrl.northumbria.ac.uk/id/eprint/42408

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