Mortality and Morbidity of Locally-Acquired Hepatitis E in the National Scottish Cohort: A Multicentre Retrospective Study

Wallace, Sebastian, Swann, Rachael, Donnelly, Mhairi, Kemp, Linda, Guaci, Julia, Murray, Aimee, Spoor, Johannes, Lin, Nan, Miller, Michael, Dalton, Harry, Hussaini, Hyder, Gunson, Rory, Simpson, Kenneth, Stanley, Adrian and Fraser, Andrew (2020) Mortality and Morbidity of Locally-Acquired Hepatitis E in the National Scottish Cohort: A Multicentre Retrospective Study. Alimentary Pharmacology and Therapeutics, 51 (10). pp. 974-986. ISSN 0269-2813

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Official URL: https://doi.org/10.1111/apt.15704

Abstract

Summary Background: Hepatitis E virus (HEV) is the most common acute viral hepatitis in Scotland. Little is known about the burden of morbidity and mortality, which can be high in chronic liver disease or immunocompromised states. Aims: The study aims to record the morbidity and mortality of HEV in Scotland. Methods: Demographic, clinical and laboratory data were collected retrospectively from all cases of HEV reported to virology departments across 9 NHS health boards, between January 2013 and January 2018. Results: 511 cases were included (Mean age 62, 64% male). 58 (11%) cases had pre-existing cirrhosis and 110 (21%) had diabetes. 303 patients required admission (59%), totalling 2747 inpatient-bed-days. 17 (3.3%) HEV related deaths were recorded. Factors that predicted mortality included haematological malignancy (OR 51.56, 95% CI 3.40-782.83, p=0.005), cirrhosis (OR 41.85, 95% CI 2.85-594.16, p= 0.006), higher serum bilirubin (OR 1.01, 95% CI 1.01-1.02, p=0.011) and chronic HEV infection (OR 0.02, 95% CI 0.02- 0.28, p=<0.001). HEV infection affected 35 transplant patients of 106 total immunosuppressed patients (21%). Of these, 25 patients received Ribavirin therapy with a sustained virological remission of 76%. 35 (6.7%) patients developed acute or acute-on-chronic liver failure with 2 requiring transplant. 37 (7.2%) patients reported neurological complications with 10 developing neuralgic amyotrophy, 6 Guillain-Barré and 2 encephalitis. 44 (8.6%) patients developed acute kidney injury. Conclusion: In Scotland, HEV causes a significant burden of inpatient admissions, organ failure and death. Cirrhosis and haematological malignancy are significant predictors of mortality. Neurological and renal complications occur in a significant minority.

Item Type: Article
Subjects: A300 Clinical Medicine
B100 Anatomy, Physiology and Pathology
B900 Others in Subjects allied to Medicine
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: Elena Carlaw
Date Deposited: 31 Mar 2020 08:35
Last Modified: 04 May 2020 15:15
URI: http://nrl.northumbria.ac.uk/id/eprint/42615

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