Implications of apolipoprotein E genotype on inflammation and vitamin E status

Huebbe, Patricia, Lodge, John and Rimbach, Gerald (2010) Implications of apolipoprotein E genotype on inflammation and vitamin E status. Molecular Nutrition & Food Research, 54 (5). pp. 623-630. ISSN 1613-4125

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Official URL: http://dx.doi.org/10.1002/mnfr.200900398

Abstract

In Western societies the apolipoprotein E4 (apoE4) genotype is associated with increased morbidity and mortality and represents a significant risk factor for cardiovascular and Alzheimer's disease. In a recent study we observed significantly lower tissue α-tocopherol (α-TOH) concentrations in apoE4 compared with apoE3 mice. Furthermore, genes encoding for proteins involved in peripheral α-TOH transport and degradation were affected by the apoE genotype. Thus, the apoE4 genotype may be associated with lower vitamin E retention in peripheral tissues. This is possibly related to an altered lipoprotein metabolism including increased α-TOH retention in LDL, a decreased expression of lipoprotein receptors and impaired cellular vitamin E delivery system, and a greater intracellular degradation of tocopherols in the apoE4 genotype. An increasing number of studies in cultured cells, transgenic mice and human volunteers indicate a more pro-inflammatory state associated with the apoE4 allele. In apoE4 macrophages there is an enhanced transactivation of the key redox sensitive transcription factor NF-κB accompanied by a higher production of pro-inflammatory molecules (tumor necrosis factor α, interleukin 1β, macrophage inflammatory protein 1-α) and a lower production of anti-inflammatory interleukin 10, as compared with apoE3 macrophages. Both tissue vitamin E retention and biomarkers of chronic inflammation may be affected by the apoE genotype.

Item Type: Article
Uncontrolled Keywords: Apolipoprotein E genotype, cytokine, inflammation, tocopherol, vitamin E
Subjects: B400 Nutrition
C900 Others in Biological Sciences
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Ay Okpokam
Date Deposited: 19 Dec 2011 11:27
Last Modified: 24 Oct 2017 11:26
URI: http://nrl.northumbria.ac.uk/id/eprint/4269

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