Differences in Respiratory Muscle Responses to Hyperpnea or Loaded Breathing in COPD

Rodrigues, Antenor, Louvaris, Zafeiris, Dacha, Sauwaluk, Janssens, Wim, Pitta, Fabio, Vogiatzis, Ioannis, Gosselink, Rik and Langer, Daniel (2019) Differences in Respiratory Muscle Responses to Hyperpnea or Loaded Breathing in COPD. Medicine & Science in Sports & Exercise, 52 (5). pp. 1126-1134. ISSN 0195-9131 (In Press)

[img] Text
Rodrigues and Louvaris_Manuscript_2ndRev220092019_marked-2.pdf - Accepted Version
Restricted to Repository staff only until 23 December 2020.
Available under License Creative Commons Attribution Non-commercial 4.0.

Download (673kB) | Request a copy
Official URL: https://doi.org/10.1249/mss.0000000000002222

Abstract

Introduction
We aimed to compare acute mechanical and metabolic responses of the diaphragm and rib cage inspiratory muscles during two different types of respiratory loading in patients with COPD.
Methods
In 16 patients (age:65±13, 56% male, FEV1:60±6%pred, Pimax:82±5%pred) assessments of respiratory muscle electromyography (EMG), esophageal (Pes) and gastric (Pga) pressures, breathing pattern, and noninvasive assessments of systemic (VO2, cardiac output, oxygen delivery and extraction) and respiratory muscle hemodynamic and oxygenation responses (blood flow index [BFI], oxygen delivery index, deoxyhemoglobin concentration [HHb] and tissues oxygen saturation [StiO2]), were performed during hyperpnea and loaded breathing.
Results
During hyperpnea, breathing frequency, minute ventilation, esophageal and diaphragm pressure-time product (PTP)/min, cardiac output and VO2 were higher than during loaded breathing (P<0.05). Average inspiratory Pes and Pdi per breath, scalene (SCA), sternocleidomastoid (SCM), and intercostal muscle activation were higher during loading breathing compared to hyperpnea (P<0.05). Higher Pdi during loaded breathing compared to hyperpnea was mostly due to higher inspiratory Pes (P<0.05). Diaphragm activation, inspiratory and expiratory Pga and rectus abdominis muscle activation did not differ between the two conditions (P>0.05). SCA-BFI and oxygen delivery index were lower, and SCA-HHb was higher during loaded breathing compared to hyperpnea. Furthermore, SCA and intercostal muscle StiO2 were lower during loaded breathing compared to hyperpnea (P<0.05).
Conclusion
Greater inspiratory muscle effort during loaded breathing evoked larger ribcage and neck muscle activation compared to hyperpnea. In addition, lower SCA and intercostal muscle StiO2 during loaded breathing compared to hyperpnea indicates a mismatch between inspiratory muscle oxygen delivery and utilization induced by the former condition.

Item Type: Article
Uncontrolled Keywords: Respiratory muscle activation, respiratory muscle loading, respiratory muscle metabolism, respiratory muscle training.
Subjects: C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Elena Carlaw
Date Deposited: 07 Apr 2020 11:29
Last Modified: 07 Apr 2020 12:15
URI: http://nrl.northumbria.ac.uk/id/eprint/42721

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics