Mass spectrometry approaches for vitamin E research

Lodge, John (2008) Mass spectrometry approaches for vitamin E research. Biochemical Society Transactions, 36 (5). pp. 1066-1070. ISSN 0300-5127

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Abstract

Vitamin E is an important nutrient with antioxidant and non-antioxidant functions, and certain evidence suggests that it has a cardiovascular protective role. It is therefore important to maintain an optimal vitamin E status. In the present paper, a number of MS applications to monitor vitamin E status and its interactions, including the use of stable-isotope-labelled vitamin E and metabonomics, are highlighted. Specifically, stable-isotope studies have been used to monitor vitamin E absorption, hepatic processing and lipoprotein transport. As oxidative stress may influence vitamin E status, a number of studies comparing vitamin E biokinetics and metabolism in cigarette smokers and non-smokers have been able to show differences in vitamin E processing in smokers. Metabonomics represents a method to identify changes to metabolite profiles, offering the potential to investigate interactions between vitamin E and metabolic pathways. These applications represent innovative approaches to investigate the role of vitamin E in health and disease.

Item Type:	Article
Uncontrolled Keywords:	biokinetics, metabonomics, oxidative stress, smoking, tocopherol, vitamin E
Subjects:	B400 Nutrition C700 Molecular Biology, Biophysics and Biochemistry C900 Others in Biological Sciences
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Ay Okpokam
Date Deposited:	19 Dec 2011 12:08
Last Modified:	12 Oct 2019 17:31
URI:	http://nrl.northumbria.ac.uk/id/eprint/4273

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