Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Hilgen, Gerrit, Pirmoradian, Sahar, Pamplona, Daniela, Kornprobst, Pierre, Cessac, Bruno, Hennig, Matthias H. and Sernagor, Evelyne (2017) Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina. Scientific Reports, 7 (1). p. 42330. ISSN 2045-2322

[img]
Preview
Text
srep42330.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (7MB) | Preview
Official URL: https://doi.org/10.1038/srep42330

Abstract

We have investigated the ontogeny of light-driven responses in mouse retinal ganglion cells (RGCs). Using a large-scale, high-density multielectrode array, we recorded from hundreds to thousands of RGCs simultaneously at pan-retinal level, including dorsal and ventral locations. Responses to different contrasts not only revealed a complex developmental profile for ON, OFF and ON-OFF responses, but also unveiled differences between dorsal and ventral RGC responses. At eye-opening, dorsal RGCs of all types were more responsive to light, perhaps indicating an environmental priority to nest viewing for pre-weaning pups. The developmental profile of ON and OFF responses exhibited antagonistic behaviour, with the strongest ON responses shortly after eye-opening, followed by an increase in the strength of OFF responses later on. Further, we found that with maturation receptive field (RF) center sizes decrease, spike-triggered averaged responses to white noise become stronger, and centers become more circular while maintaining differences between RGC types. We conclude that the maturation of retinal functionality is not spatially homogeneous, likely reflecting ecological requirements that favour earlier maturation of the dorsal retina.

Item Type: Article
Subjects: C400 Genetics
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Elena Carlaw
Date Deposited: 12 May 2020 15:56
Last Modified: 12 May 2020 16:00
URI: http://nrl.northumbria.ac.uk/id/eprint/43103

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics