Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Mikhaylov, Roman, Wu, Fangda, Wang, Hanlin, Clayton, Aled, Sun, Chao, Xie, Zhihua, Liang, Dongfang, Dong, Yinhua, Yuan, Fan, Moschou, Despina, Wu, Zhenlin, Shen, Ming Hong, Yang, Jian, Fu, Richard, Yang, Zhiyong, Burton, Christian, Errington, Rachel J., Wiltshire, Marie and Yang, Xin (2020) Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip. ISSN 1473-0197 (In Press)

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Development and Characterisation of Acoustofluidic Devices Using Detachable Electrodes Made from PCB.pdf - Accepted Version
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Official URL: https://doi.org/10.1039/C9LC01192G

Abstract

Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. In this paper, we develop a novel and simple technology to fabricate a surface acoustic wave (SAW)-based acoustofluidic device by clamping electrodes made using a printed circuit board (PCB) with a piezoelectric substrate. The PCB-based SAW (PCB-SAW) device is systematically characterised and benchmarked with a SAW device made using the conventional photolithography process with the same specifications. Microparticle manipulations such as streaming in droplets and patterning in microchannels were demonstrated in the PCB-SAW device. In addition, the PCB-SAW device was applied as an acoustic tweezer to pattern lung cancer cells to form three or four traces inside the microchannel in a controllable manner. Cell viability of ∼97% was achieved after acoustic manipulation using the PCB-SAW device, which proved its ability as a suitable tool for acoustophoretic applications.

Item Type: Article
Subjects: C100 Biology
F100 Chemistry
F200 Materials Science
F300 Physics
H600 Electronic and Electrical Engineering
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: John Coen
Date Deposited: 13 May 2020 11:40
Last Modified: 18 May 2020 08:00
URI: http://nrl.northumbria.ac.uk/id/eprint/43123

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