The Streptococcus equi prophage-encoded protein SEQ2045 is a hyaluronan-specific hyaluronate lyase that is produced during equine infection

Lindsay, Anna-Marie, Zhang, Meng, Mitchell, Zoe, Holden, Matthew, Waller, Andrew, Sutcliffe, Iain and Black, Gary (2009) The Streptococcus equi prophage-encoded protein SEQ2045 is a hyaluronan-specific hyaluronate lyase that is produced during equine infection. Microbiology, 155 (2). pp. 443-449. ISSN 1350-0872

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Official URL: http://dx.doi.org/10.1099/mic.0.020826-0

Abstract

Streptococcus equi causes equine ‘strangles’. Hyaluronate lyases, which degrade connective tissue hyaluronan and chondroitins, are thought to facilitate streptococcal invasion of the host. However, prophage-encoded hyaluronate lyases are hyaluronan-specific and are thought to be primarily involved in the degradation of the hyaluronan capsule of streptococci during bacteriophage infection. To understand the role of prophage-encoded hyaluronate lyases further, we have biochemically characterized such a hyaluronate lyase, SEQ2045 from S. equi, and have shown that it is produced during equine infection. Prophage-encoded hyaluronan-specific hyaluronate lyases may therefore play a more direct role in disease pathogenesis than previously thought.

Item Type: Article
Uncontrolled Keywords: streptococcus equi, lyases
Subjects: C500 Microbiology
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 29 Jan 2010 16:53
Last Modified: 10 Aug 2015 11:44
URI: http://nrl.northumbria.ac.uk/id/eprint/509

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